{"id":3254,"date":"2022-05-09T11:45:53","date_gmt":"2022-05-09T11:45:53","guid":{"rendered":"https:\/\/scientificasia.org\/?p=3254"},"modified":"2022-05-09T11:45:55","modified_gmt":"2022-05-09T11:45:55","slug":"a-new-peptide-active-against-certain-cancers-is-identified","status":"publish","type":"post","link":"https:\/\/scientificasia.org\/index.php\/2022\/05\/09\/a-new-peptide-active-against-certain-cancers-is-identified\/","title":{"rendered":"A new peptide active against certain cancers is identified"},"content":{"rendered":"\n<p>Demand for new kinds of antibiotics is surging, as drug-resistant and emerging infections are becoming an increasingly serious global health threat. Researchers are racing to reexamine certain microbes that serve as one of our most successful sources of therapeutics: the actinomycetes.<\/p>\n\n\n\n<p>A team of U.S. researchers has <a rel=\"noreferrer noopener\" href=\"https:\/\/phys.org\/news\/2022-04-rare-soil-microbe-antibiotic-candidate.html\" target=\"_blank\">identified<\/a> a rare bacterium that is active against certain cancers. The bacterium, Lentzeaflaviverrucosa, that produces petrichorin A.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"A new peptide active against certain cancers is identified\" width=\"770\" height=\"433\" src=\"https:\/\/www.youtube.com\/embed\/btn6tcUkvoc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>\u201cRare actinomycetes are an underexploited source of new bioactive compounds,\u201d said Joshua Blodgett, assistant professor of biology in Arts &amp; Sciences, co-corresponding author of the new study. \u201cOur genomics-based approach allowed us to identify an unusual peptide for future drug design efforts.\u201d<\/p>\n\n\n\n<p>Petrichorin A, a dumbbell-like natural product, was evaluated for anti-cancer activity against multiple cancer cell lines. The researchers conducted a preliminary test and discovered that petrichor in A was not toxic to a normal human cell line. With this observation, his team proved that petrichor in A was active against ovarian cancer, fibrosarcoma, prostate cancer, and T-cell leukemia. This highlighted the importance of including petrichor in A in future research on pharmaceutical design and discovery programs.<\/p>\n\n\n\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5222637924397992\"\n     crossorigin=\"anonymous\"><\/script>\n<ins class=\"adsbygoogle\"\n     style=\"display:block; text-align:center;\"\n     data-ad-layout=\"in-article\"\n     data-ad-format=\"fluid\"\n     data-ad-client=\"ca-pub-5222637924397992\"\n     data-ad-slot=\"1054784925\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n","protected":false},"excerpt":{"rendered":"<p>Demand for new kinds of antibiotics is surging, as drug-resistant and emerging infections are becoming an increasingly serious global health threat. Researchers are racing to reexamine certain microbes that serve as one of our most successful sources of therapeutics: the actinomycetes. A team of U.S. researchers has identified a rare bacterium that is active against [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3255,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[44],"tags":[100,981,647,1023,159,759,1024,1021,1025,660,1020,1018,1016,777,1015,1022,1014,1019,1017],"class_list":["post-3254","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-antibiotics","tag-anticancer","tag-bioactive-compounds","tag-biotechnology","tag-cancer","tag-chemistry","tag-discovery-research","tag-drug-design","tag-drug-discovery","tag-drug-resistance","tag-gene-clustering","tag-genomic-regions","tag-microbial-infections","tag-microbiology","tag-oncology","tag-peptides","tag-petrichorin","tag-soil-bacteria","tag-soils"],"_links":{"self":[{"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/posts\/3254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/comments?post=3254"}],"version-history":[{"count":1,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/posts\/3254\/revisions"}],"predecessor-version":[{"id":3256,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/posts\/3254\/revisions\/3256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/media\/3255"}],"wp:attachment":[{"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/media?parent=3254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/categories?post=3254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificasia.org\/index.php\/wp-json\/wp\/v2\/tags?post=3254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}